There will be no relationship between him and Andrea.
They already gave Dale's knife idea at the prison to Rick.
We will never see Dale stand up and inform Rick that he is no longer the group's leader, and that he will share authority with Dale, Tyreese and Hershel.
Dale and Andrea will never become adopted parents of Donna and Allen’s orphaned children.
We will never see Dale and Andrea hiding in the RV as the prison is overrun by zombies.
We will never see the intense emotional scene where Dale is bitten by a zombie and they have to rush and amputate his leg.
We will never see the story line where dale is jealous because he thinks Andrea is cheating on him with Tyreese and he tells her she deserves to be with a much younger man, only to find out they were spending their time building him a prosthetic leg.
We will never see when he hides his wound and goes into the forest to die, only to be kinapped by the cannibals who he doesn't tell about his infection.